Abstract
One Border One Health is the first initiative of its kind along the U.S.-Mexico border. It is a binational, multidisciplinary, cross-sectoral initiative reconfiguring traditional species-specific approaches to surveillance for emerging and re-emerging pathogens in the California/Baja California region. Recognizing the diverse animal, human, and environmental geographies in the region and the health risks posed by these animal-human-environmental interfaces, the Early Warning Infectious Disease Surveillance Program (EWIDS) founded One Border One Health in 2011 to address disease emergence using a comprehensive One Health paradigm for surveillance, informatics, and education and outreach.