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Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study

Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study

Reduced pulmonary function is known to be an indicator of systemic aging and has been linked to increased mortality and morbidity in older adults [39,40]. This suggests that maintaining optimal lung function could be crucial in mitigating the effects of biological aging and improving overall health outcomes. The association between smoking status and predicted biological age is well-documented in various studies.

Chang-Uk Jeong, Jacob S Leiby, Dokyoon Kim, Eun Kyung Choe

JMIR Aging 2025;8:e64473

Experiences of Birth Attendants on Upward Obstetric Emergency Referrals in Low- and Middle-Income Countries: Protocol for a Scoping Review

Experiences of Birth Attendants on Upward Obstetric Emergency Referrals in Low- and Middle-Income Countries: Protocol for a Scoping Review

SDG 3, Target 1, aims to reduce the global maternal mortality ratio (MMR) to below 70 maternal deaths per 100,000 live births by 2030. Target 2 seeks to prevent the deaths of newborns and children younger than 5 years to fewer than 25 deaths per 1000 live births and reduce neonatal mortality to 12 deaths per 1000 live births [9].

Final Z Juqu, Olivia B Baloyi, Esther L Mbobnda Kapche, Wilma ten Ham-Baloyi, Geldine Chironda, Zamadonda Nokuthula Xulu-Kasaba

JMIR Res Protoc 2025;14:e64886

Substance-Related Acute Toxicity Deaths in Canada From 2016 to 2017: Protocol for a Retrospective Chart Review Study of Coroner and Medical Examiner Files

Substance-Related Acute Toxicity Deaths in Canada From 2016 to 2017: Protocol for a Retrospective Chart Review Study of Coroner and Medical Examiner Files

Between January 2016 and June 2023, a total of 40,642 people died of opioid toxicity alone, with associated mortality rates increasing over time [1]. Compared to other countries where data are available, the United States and Canada have seen rapid escalations and persistently high accidental acute toxicity mortality rates [2]. Information on the characteristics and circumstances of those who have died is critical to informing and evaluating strategies aimed at preventing harms.

Jenny Rotondo, Amanda VanSteelandt, Fiona Kouyoumdjian, Matthew J Bowes, Tanya Kakkar, Graham Jones, Brandi Abele, Regan Murray, Emily Schleihauf, Jessica Halverson, Jennifer Leason, Dirk Huyer, Beth Jackson, Songul Bozat-Emre, Devanshi Shah, Erin E Rees

JMIR Public Health Surveill 2025;11:e49981

A Risk Prediction Model (CMC-AKIX) for Postoperative Acute Kidney Injury Using Machine Learning: Algorithm Development and Validation

A Risk Prediction Model (CMC-AKIX) for Postoperative Acute Kidney Injury Using Machine Learning: Algorithm Development and Validation

This condition not only escalates morbidity but also substantially increases in-hospital mortality by approximately 3- to 9-fold [2]. The severity of this risk is further underscored in patients who developed postoperative AKI after intraabdominal surgery, as a large-scale study reported a 15-fold higher risk of mortality in patients with AKI compared to those without AKI [3].

Ji Won Min, Jae-Hong Min, Se-Hyun Chang, Byung Ha Chung, Eun Sil Koh, Young Soo Kim, Hyung Wook Kim, Tae Hyun Ban, Seok Joon Shin, In Young Choi, Hye Eun Yoon

J Med Internet Res 2025;27:e62853

Media Framing and Portrayals of Ransomware Impacts on Informatics, Employees, and Patients: Systematic Media Literature Review

Media Framing and Portrayals of Ransomware Impacts on Informatics, Employees, and Patients: Systematic Media Literature Review

In addition, there is growing evidence from clinical practice and research that ransomware attacks impact patient morbidity and mortality. Ghafur et al [61] analyzed the negative outcomes of the National Health Service in Great Britain after the 2017 Wanna Cry ransomware attack. They found that although there were no statistically significant differences in mortality rates compared to the baseline, there was an economic impact of £5.9 million (US $7.7 million).

Atiya Avery, Elizabeth White Baker, Brittany Wright, Ishmael Avery, Dream Gomez

J Med Internet Res 2025;27:e59231

Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

In this case, the mortality rate is very high. Although similar research has not been conducted in Finland, the situation is presumed to be equally concerning. There are automated methodologies implemented to diagnose liver fibrosis, but large-scale systematic analysis and screening are still yet to be implemented because of missing nationwide data. One randomized controlled study developed a care pathway for identifying advanced liver disease in patients with type 2 diabetes in Hong Kong and Malaysia.

Viljami Männikkö, Janne Tommola, Emmi Tikkanen, Olli-Pekka Hätinen, Fredrik Åberg

JMIR Med Inform 2025;13:e62978

Effect of a Telemedicine Model on Patients With Heart Failure With Reduced Ejection Fraction in a Resource-Limited Setting in Vietnam: Cohort Study

Effect of a Telemedicine Model on Patients With Heart Failure With Reduced Ejection Fraction in a Resource-Limited Setting in Vietnam: Cohort Study

Despite significant advances in HF treatment over the past decades, mortality rates remain high, with 1-year mortality rates ranging from 14% to 30% and 5-year rates ranging from 50% to 75% [3,5]. Additionally, patients with HF frequently require hospitalization due to acute exacerbations of the disease, making HF the leading cause of hospitalization for individuals older than 65 years in Europe [2,5-7].

Hoai Thi Thu Nguyen, Hieu Ba Tran, Phuong Minh Tran, Hung Manh Pham, Co Xuan Dao, Thanh Ngoc Le, Loi Doan Do, Ha Quoc Nguyen, Thom Thi Vu, James Kirkpatrick, Christopher Reid, Dung Viet Nguyen

J Med Internet Res 2025;27:e67228

Comparative Evaluation of Effectiveness of Standard of Care Alone and in Combination With Homoeopathic Treatment in COVID-19–Related Rhino-Orbito-Cerebral Mucormycosis (ROCM): Protocol for a Single Blind, Randomized Controlled Trial

Comparative Evaluation of Effectiveness of Standard of Care Alone and in Combination With Homoeopathic Treatment in COVID-19–Related Rhino-Orbito-Cerebral Mucormycosis (ROCM): Protocol for a Single Blind, Randomized Controlled Trial

Despite all efforts in the conventional line of treatment, ROCM has a mortality rate of 40%-50% and 70% of survivors are left with residual defects [18]. To reduce the high mortality rate and residual defect in most of the survivors, Ministry of AYUSH, Government of India [19] has recommended homoeopathy as an add-on therapy to maximize the effectiveness of the standard line of treatment in conventional therapy.

Harleen Kaur, Jyoti Sachdeva, Ramesh Bawaskar, Twinkle Goyal

JMIR Res Protoc 2025;14:e57905

Targeted Behavior Change Communication Using a Mobile Health Platform to Increase Uptake of Long-Lasting Insecticidal Nets Among Pregnant Women in Tanzania: Hati Salama “Secure Voucher” Study Cluster Randomized Controlled Trial

Targeted Behavior Change Communication Using a Mobile Health Platform to Increase Uptake of Long-Lasting Insecticidal Nets Among Pregnant Women in Tanzania: Hati Salama “Secure Voucher” Study Cluster Randomized Controlled Trial

Pregnant women and adolescents are at heightened risk of morbidity and mortality by malaria, with 22% of pregnant women exposed to malaria in East and Southern Africa in 2020 [1]. Malaria infection during pregnancy can result in miscarriage, premature delivery, low birth weight, or death in neonates, as well as maternal anemia and maternal death [2].

Trinity Vey, Eleonora Kinnicutt, Andrew G Day, Nicola West, Jessica Sleeth, Kenneth Bernard Nchimbi, Karen Yeates

J Med Internet Res 2025;27:e51524