In public health reporting, a distinction is made between Canadian-acquired and international travel-related cases, but there is no differentiation between domestic travel-related and endemic cases. The objective of this presentation is to explore how demographic and exposure factors related to giardiasis vary between travel and endemic cases, for residents of the Region of Waterloo (Ontario). We found that exposure to risk factors for giardiasis varies among domestic-travel, international-travel, and endemic cases. Consequently, a distinction should be made between these case types in developing prevention strategies.