Super Bowl XLIX took place on February 1st, 2015 in Glendale, Arizona. In preparation for this large scale public event and related activities, the Maricopa County Department of Public Health developed methods for enhanced surveillance, situational awareness and early detection of public health emergencies. This presentation describes enhanced epidemiologic surveillance efforts in place during Super Bowl XLIX and associated events. A summary of surveillance result highlights will be presented. Lessons learned from surveillance strategies implemented during mass gatherings will be reviewed and novel approaches for near real-time surveillance for situational awareness and early event detection will be examined.