The objective of this presentation is to evaluate progress in the development of semantically interoperable content for public health (PH) systems that monitor PH threats. It was demonstrated that while progress towards content standardization for exchange of these data exists, there are some gaps that became evident through this study. Our results demonstrate that content standards for monitoring PH threats at a patient-level are better defined than at population level. Results of this study underline the importance of better coordination of data harmonization efforts between and within domains of PH knowledge.