A recent assessment of the Sudan public health surveillance system found fragmented and siloed disease programs and an overburdened workforce due to vertical systems and inefficient processes. A plan of action was developed to support improving public health surveillance strengthening by: 1) implementing a strategic approach to achieving IHR (2005), 2) implementing One Health and IDSR aims, and 3) establishing an E-surveillance ICT platform for increasing public health surveillance capacity to safely and rapidly detect and report infectious diseases in Sudan.