The National Biosurveillance Integration Center (NBIC) Strategic Plan and innovative biosurveillance projects begun by the NBIC will be presented. The Strategic Plan defines a new approach to realizing the mission and vision of the NBIC, identifying core disciplines of biosurveillance integration as well as the goals and objectives of the center. The plan explains the Center''s approach to integrating national biosurveillance information to provide relevant and timely information that effectively supports decision making. Innovative biosurveillance investigative projects underway involving emergency medical system data, changes to poison control center data collection, and social media analyses will also be discussed.